Herz & Kreislauf
Der kardiovaskuläre Forschungsbereich der MHB hat die Erforschung von kardiovaskulären Erkrankungen (KVE), ihrer Epidemiologie, Vorhersage, Prävention und Behandlung im Alter zum Ziel.
Dieses Konzept findet in der Struktur der Medizinischen Hochschule Brandenburg einen fruchtbaren Boden, da hier in der Non-Metropol-Region die medizinisch-demographischen Verhältnisse der Zukunft abgebildet sind. Im Jahr 2030 wird mehr als ein Drittel der Bevölkerung 65 Jahre und älter sein. Die Folgen des demographischen Wandels im Flächenland Brandenburg, die sich besonders an der Peripherie des Landes zeigen, können nach aktuellen Rechnungen dazu führen, dass die medizinische Versorgung der Bevölkerung nicht mehr flächendeckend gewährleistet werden kann. Exemplarisch sei hier die im Vergleich der Bundesländer seit Jahren höchste Sterblichkeitsrate aufgrund von Herzinfarkten im Bundesland Brandenburg genannt.
Um sich den Herausforderungen einer älteren und multimorbiden Bevölkerung in der Fläche mit wenig Zugriff auf medizinische Ressourcen zu stellen, entwickelt der Forschungsbereich KVE zukunftsorientierte, demographierelevante Konzepte. Die Heterogenität der Gesundheitsregionen im Land Brandenburg ist eine günstige Voraussetzung für nachhaltige, innovative und sektorenübergreifende Versorgungskonzepte.
Leitgedanke ist die strikte qualitätsorientierte Ausrichtung der Forschung im Sinne hochwertiger und international akzeptierter Forschungsstandards.
Prof. Dr. med.
Oliver Ritter
Professur für Innere Medizin: Kardiologie
Telefonnummer: +49 3381 41-1500
E-Mail:
oliver.ritter@mhb-fontane.de
Paper of the Month
Februar
Kostin S, Giannakopoulos T, Richter M, Krizanic F, Sasko B, Ritter O, Pagonas N
Coronary microthrombi in the failing human heart: the role of von Willebrand factor and PECAM-1
Mol Cell Biochem. 2024 Dec;479(12):3437-3446 Epub 2024 Feb 21.
DOI: 10.1007/s11010-024-04942-0
The recognition of microthrombi in the heart microcirculation has recently emerged from studies in COVID-19 decedents. The present study investigated the ultrastructure of coronary microthrombi in heart failure (HF) due to cardiomyopathies that are unrelated to COVID-19 infection. In addition, we have investigated the role of von Willebrand factor (VWF) and PECAM-1 in microthrombus formation. We used electron microscopy to investigate the occurrence of microthrombi in patients with HF due to dilated (DCM, n = 7), inflammatory (MYO, n = 6) and ischemic (ICM, n = 7) cardiomyopathy and 4 control patients. VWF and PECAM-1 was studied by quantitative immunohistochemistry and Western blot. In comparison to control, the number of microthrombi was increased 7-9 times in HF. This was associated with a 3.5-fold increase in the number of Weibel-Palade bodies (WPb) in DCM and MYO compared to control. A fivefold increase in WPb in ICM was significantly different from control, DCM and MYO. In Western blot, VWF was increased twofold in DCM and MYO, and more than threefold in ICM. The difference between ICM and DCM and MYO was statistically significant. These results were confirmed by quantitative immunohistochemistry. Compared to control, PECAM-1 was by approximatively threefold increased in all groups of patients. This is the first study to demonstrate the occurrence of microthrombi in the failing human heart. The occurrence of microthrombi is associated with increased expression of VWF and the number of WPb, being more pronounced in ICM. These changes are likely not compensated by increases in PECAM-1 expression.
Januar
Kostin S, Richter M, Krizanic F, Sasko B, Kelesidis T, Pagonas N
NETosis Is an Important Component of Chronic Myocardial Inflammation in Patients With Heart Failure
Circ Heart Fail. 2025 Jan;18(1):e012231.
DOI: 10.1161/CIRCHEARTFAILURE.124.012231
No abstract available
Dezember
Dai M, Li K, Sacirovic M, Zemmrich C, Ritter O, Bramlage P, Persson AB, Buschmann E, Buschmann I, Hillmeister P
Cell-free plasma telomere length correlated with the risk of cardiovascular events using machine learning classifiers
Sci Rep. 2024 Dec 5;14(1):30390.
DOI: 10.1038/s41598-024-76686-2
Das Projekt Endothelial Health & VascularAge (EHVA) der Klinik für Angiologie etabliert derzeit verschiedene molekulare Marker zur Bestimmung des vaskulären Alters. Telomerlängen im zellfreien Blutplasma (cf-TL) könnten dabei ein neuer Biomarker sein, da in dieser Studie ein Zusammenhang zwischen cf-TL, Stickstoffmonoxid (NOx) und Endothelfunktion nachgewiesen wurde – wobei NOx und Endothelfunktion bekannte Indikatoren für das biologische Alter und eine gestörte Gefäßfunktion bei Herz-Kreislauf-Erkrankungen sind. Der Einsatz von Machine-Learning-Modellen zeigte zudem, dass cf-TL insbesondere zur Vorhersage von Herzinsuffizienz beiträgt, während sein Wert für die Klassifikation koronarer Herzkrankheit (CAD) geringer ausfiel. cf-TL könnte daher ein vielversprechender Biomarker für die frühzeitige Erkennung und Risikoeinschätzung von Herzinsuffizienz sein und sollte in zukünftigen Studien weiter untersucht werden.
This retrospective study explored the association between circulating cell-free plasma telomere length (cf-TL) and coronary artery disease (CAD) and heart failure (HF). Data from 518 participants were collected, including clinical and laboratory data. cf-TL was measured in plasma samples and machine learning (ML) classification models were developed to differentiate between CAD, HF and control conditions. Our results showed that cf-TL was significantly prolonged in HF patients compared to controls, but no significant difference was observed between CAD patients and controls. Additionally, cf-TL was significantly correlated with nitric oxide metabolites (NOx) and flow-mediated dilation (FMD), suggesting a potential link with endothelial function. To avoid data leakage and ensure the model captured only relationships relevant to the research question, we utilized a temporal data split, holding out the last year's data for testing (n = 81) and using the remaining data for training (n = 324) and validation (n = 109). The ML models using four variables achieved an area under the curve (AUC) of 0.795 in the validation dataset and 0.717 in the test dataset for CAD classification, and 0.829 in the validation dataset and 0.806 in the test dataset for HF classification. SHAP analysis revealed that cf-TL had minimal impact on the predictions of the CAD model, as indicated by consistently low SHAP values, whereas in the HF model, cf-TL exhibited a broader range of SHAP values, indicating a greater contribution to the model's classification. These findings suggest that cf-TL may play a more prominent role in HF pathophysiology and could serve as a valuable biomarker for predicting HF risk. Further studies are warranted to explore cf-TL's diagnostic and prognostic potential across different cardiovascular diseases.
November
Stocker TJ, Stolz L, Karam N, Kalbacher D, Koell B, Trenkwalder T, Xhepa E, Adamo M, Spieker M, Horn P, Butter C, Weckbach LT, Novotny J, Melica B, Giannini C, von Bardeleben RS, Pfister R, Praz F, Lurz P, Rudolph V, Metra M, Hausleiter J; EuroSMR Investigators
Long-Term Outcomes After Edge-to-Edge Repair of Secondary Mitral Regurgitation: 5-Year Results From the EuroSMR Registry
JACC Cardiovasc Interv. 2024 Nov 11;17(21):2543-2554.
DOI: 10.1016/j.jcin.2024.08.016
In einer großen europäischen Registerstudie wurde die langfristige Wirksamkeit einer speziellen Form der Mitralklappen-Reparatur mittels Klippsystem bei >1.600 Patienten untersucht. Die 5-Jahres-Überlebensrate lag bei 35,0 %. Die Studie identifiziert Faktoren, die das langfristige Überleben beeinflussen, wie die Nierenfunktion und der Schweregrad einer vorbestehenden Herzschwäche. Die Daten liefern damit wertvolle Erkenntnisse für die Wirksamkeit des Eingriffs und die Optimierung der Patientenauswahl.
Background: Mitral valve transcatheter edge-to-edge repair (M-TEER) reduces secondary mitral regurgitation (MR) in heart failure and impacts survival in selected patients as demonstrated in the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation) trial. However, long-term outcome data after M-TEER under real-world conditions are lacking.
Objectives: This study sought to assess long-term efficacy and survival after M-TEER in a large real-world registry.
Methods: We analyzed patients with significant secondary MR undergoing M-TEER from the EuroSMR (European Registry of Transcatheter Repair for Secondary Mitral Regurgitation) registry. Long-term MR reduction, functional outcomes, survival rate, and predictors for all-cause mortality were assessed.
Results: In this study, 1,628 patients undergoing M-TEER (mean age 73.8 years, mean EuroSCORE II [European System for Cardiac Operative Risk Evaluation II] 6.9%, 86.6% NYHA functional class ≥III) with available long-term data were included. Five-year survival was 35.0%. Long-term MR reduction (MR grade ≤2+: baseline 4.1%, discharge 92.2%, 5-year follow-up 85.5%; P < 0.001) and functional improvement (NYHA ≤II: baseline 13.4%, 5-year follow-up 60.1%; P < 0.001) was observed. The degree of residual MR was associated with 5-year survival (residual MR grade ≤1+: 38.6%; 2+: 30.5%; ≥3+: 22.6%; P < 0.001). Independent predictors for 5-year all-cause mortality post-M-TEER included age, renal function, residual MR, NYHA functional class, left ventricular ejection-fraction, and COAPT trial eligibility (P < 0.01 for all).
Conclusions: This extensive multicenter registry underscores the long-term efficacy of M-TEER in real-world clinical practice and identifies predictors for long-term survival. These findings contribute valuable insights for optimizing patient selection in routine clinical interventions.
Oktober
Schlegl J, Bannehr M, Kücken T, Jankowska P, Neuss M, Lichtenauer M, Haase-Fielitz A, Butter C, Edlinger C
Bibliometric analysis of imaging and treatment strategies for severe tricuspid regurgitation from 2015 to 2023
Front Cardiovasc Med. 2024 Oct 29;11:1444466.
DOI: 10.3389/fcvm.2024.1444466
Die Trikuspidalklappeninsuffizienz, eine lange eher nachrangig betrachtete und vernachlässigte Herzklappenerkrankung, gerät zunehmend in den Fokus der Forschung. Zwischen 2015 und 2023 nahm die Anzahl der entsprechenden Studien weltweit deutlich zu – besonders bei kathetergestützten Eingriffen und bildgebenden Verfahren. Deutschland ist führend bei den Interventionen, die USA vor allem bei der Bildgebung. Der Forschungsschwerpunkt verlagert sich klar weg von klassischen chirurgischen Eingriffen hin zu schonenderen Interventionen – und damit einhergehend zur Bildgebung, die für Planung und Durchführung dieser Verfahren unverzichtbar ist.
Diese Bibliometrie verdeutlicht, wie sich die Forschungsschwerpunkte verändert und liefert wertvolle Erkenntnisse für eine bessere, individualisierte Patientenversorgung in einem wachsenden und noch unvollständig verstandenen Feld.
Background: Severe tricuspid regurgitation is a progressive disease with an unfavourable prognosis. In recent years there have been extraordinary gains in knowledge through both clinical and basic scientific work. We performed a bibliometric analysis on tricuspid regurgitation with a focus on imaging techniques and treatment approaches and to identify scientific milestones and emerging research trends.
Methods: Publications, published between 2015 and 2023 were identified. Study characteristics, impact factors and countries of origin studies were recorded. Heat maps were created to visualise data and to identify leading centers. Most frequently cited publications were recognised as milestones.
Results: We screened 3,519 studies. 368 studies were included, of which 326 were clinical studies. Clinical studies were further subdivided into interventional (n = 138), surgical (n = 115) or studies on imaging modalities (n = 74). We detected an enormous increase in scientific output worldwide, especially in imaging and interventional studies. The United States, Germany and Poland were identified as leading countries in imaging, interventions and preclinical studies respectively.
Conclusions: Our study reflects the global gain in knowledge over the last 9 years. We were able to identify an annually rising number of interventional studies. Imaging studies have also seen a rapid increase, especially since 2020. In recent years, we monitored a decline in surgical studies.
September
Bannehr M, Georgi C, Edlinger C, Paar V, Jankowska P, Lichtenauer M, Haase-Fielitz A, Seifert M, Butter C
Myeloperoxidase and N-terminal proatrial natriuretic peptide as predictors for atrial fibrillation recurrence in patients undergoing redo ablation
Heart Rhythm O2. 2024 Sep 13;5(11):770-777.
DOI: 10.1016/j.hroo.2024.09.003
Background
Atrial fibrillation (AF) is a progressively developing arrhythmia. Electroanatomic remodeling may play an important role, both in the development of the disease and in the perpetuation and thus in the recurrence of AF.
Objective
This study aimed to investigate potential biomarkers myeloperoxidase (MPO), N-terminal proatrial natriuretic peptide (NT-proANP), intercellular adhesion molecule-1, and matrix metalloproteinase-2 and their predictive value for AF recurrence in patients undergoing redo ablation.
Methods
In this single-center prospective cohort study, 50 consecutive patients underwent ultra high-density mapping and redo ablation. Biomarkers were determined before ablation and at 6-month follow-up. Seven-day Holter was conducted to check for AF recurrence (>30 seconds).
Results
Eleven (22%) patients showed AF recurrence after redo ablation. Receiver-operating characteristic curve analysis revealed venous MPO and NT-proANP (area under the curve [AUC] 0.755, 95% CI 0.599–0.912, P = .010; and AUC 0.752, 95% CI 0.551–0.953, P = .011) as acceptable predictors for intermediate AF recurrence, whereas matrix metalloproteinase-2, intercellular adhesion molecule-1, and established cardiovascular biomarkers such as N-terminal pro–B-type natriuretic peptide, troponin T, and C-reactive protein were not (all AUC <0.600). MPO and NT-proANP correlated with AF burden (ρ = 0.365, P = .005; and ρ = 0.362, P = .005). While MPO was associated with atrial fibrosis in the endocardial map (ρ = 0.280, P = .024), NT-proANP correlated with left atrial volume index (ρ = 0.256, P = .037). There were no significant differences in biomarkers concentrations with regard to venous and coronary sinus samples.
Conclusion
MPO and NT-proANP are of predictive value for AF recurrence in patients undergoing redo ablation. While MPO correlated with endocardial fibrosis, NT-proANP was associated with left atrial volume.
August
Seifert M, Meretz D, Haase-Fielitz A, Georgi C, Bannehr M, Moeller V, Janßen G, Bramlage P, Minden HH, Grosse-Meininghaus D, Butter C
Impact of Physical Activity in Patients With Atrial Fibrillation Undergoing Catheter Ablation: The Multicenter Randomized BE-ACTION Trial
Circ Cardiovasc Qual Outcomes. 2024 Oct;17(10):e010877.
DOI: 10.1161/CIRCOUTCOMES.124.010877
Background: Arrhythmia recurrence after pulmonary vein isolation (PVI) is common. We conducted a multicenter, randomized trial to determine the impact of increased physical activity on atrial fibrillation recurrence after PVI.
Methods: From 2018 to 2020, we randomly assigned 200 patients with atrial fibrillation to the ACTION or NO-ACTION group in 4 different centers in the local country of Brandenburg, Germany. Patients were eligible if they were scheduled to undergo PVI, aged ≥50 to ≤77 years, body mass index ≥23 to ≤35 kg/m2, and accepted wearing an activity tracker allowing 24-hour activity monitoring via mobile app. Patients in the ACTION group were actively remote-controlled via transmitted activity data by a physiotherapist, and individual motivational interviewing call sessions were scheduled with each ACTION patient every 2 weeks. The primary end point was the composite of recurrence of any atrial arrhythmia >30 seconds, additional ablation procedure, cardioversion, and new onset of antiarrhythmic drugs earliest after 90 days after index PVI over 12 months.
Results: Overall, the median age of patients was 66 (interquartile range, 61-71) years, 33.5% were women, and 52% had persistent atrial fibrillation. The number of steps per day increased in both groups of patients from baseline to 12 months (P<0.001). The absolute increase in steps per day did not differ between patients in the ACTION group with +3205 steps (597-4944) compared with those in the NO-ACTION group +2423 steps (17-4284), P=0.325. Unadjusted intention-to-treat analysis showed no difference in the primary composite end point in the ACTION group (27.3%) versus the NO-ACTION group (32.7%), P=0.405.
Conclusions: Physical activity improved in patients after PVI. The present randomized controlled trial shows that activity tracker and motivational calls to increase physical activity versus activity tracker alone did not reduce the occurrence of the primary composite end point of atrial fibrillation recurrence or the absolute increase in steps per day.
Juli
Schipmann LC, Moeller V, Krimnitz J, Bannehr M, Kramer TS, Haase-Fielitz A, Butter C
Outcome and microbiological findings of patients with cardiac implantable electronic device infection
Heart Vessels. 2024 Jul;39(7):626-639
doi: 10.1007/s00380-024-02380-y
Infektionen im Zusammenhang mit kardialen implantierbaren elektronischen Geräten (CIEDs) sind eine multifaktorielle Erkrankung, die zu erhöhter Morbidität und Mortalität führt. Ziel der Studie war es, patienten-, krankheits- und behandlungsbezogene Risikofaktoren einschließlich des mikrobiologischen und bakteriellen Spektrums für die 1- und 3-Jahres-Mortalität bei Patienten mit lokaler und systemischer CIED-Infektion zu untersuchen. Es wurden die Daten von 243 Patienten ausgewertet. Staphylokokken sind die häufigsten Erreger von CIED-Infektionen. Zu den unabhängigen Risikofaktoren für die 1-Jahres-Mortalität gehörten das Alter, NT-proBNP bei der Aufnahme, eine neu aufgetretene oder verschlimmerte Trikuspidalregurgitation und systemische Infektionen.
Introduction: Infections associated with cardiac implantable electronic devices (CIEDs) are a multifactorial disease that leads to increased morbidity and mortality.
Objective: The aim was to analyze patient-, disease- and treatment-related characteristics including microbiological and bacterial spectrum according to survival status and to identify risk factors for 1- and 3-year mortality in patients with local and systemic CIED infection.
Methods: In a retrospective cohort study, we analyzed data from patients with CIED-related local or systemic infection undergoing successful transvenous lead extraction (TLE). Survival status as well as incidence and cause of rehospitalization were recorded. Microbiology and antibiotics used as first-line therapy were compared according to mortality. Independent risk factors for 1- and 3-year mortality were determined.
Results: Data from 243 Patients were analyzed. In-hospital mortality was 2.5%. Mortality rates at 30 days, 1- and 3 years were 4.1%, 18.1% and 30%, respectively. Seventy-four (30.5%) patients had systemic bacterial infection. Independent risk factors for 1-year mortality included age (OR 1.05 [1.01-1.10], p = 0.014), NT-proBNP at admission (OR 4.18 [1.81-9.65], p = 0.001), new onset or worsened tricuspid regurgitation after TLE (OR 6.04 [1.58-23.02], p = 0.009), and systemic infection (OR 2.76 [1.08-7.03], p = 0.034), whereas systemic infection was no longer an independent risk factor for 3-year mortality. Staphylococcus aureus was found in 18.1% of patients who survived and in 25% of those who died, p = 0.092. There was a high proportion of methicillin-resistant strains among coagulase-negative staphylococci (16.5%) compared to Staphylococcus aureus (1.2%).
Conclusions: Staphylococci are the most common causative germs of CIED-infection with coagulase-negative staphylococci showing higher resistance rates to antibiotics. The independent risk factors for increased long-term mortality could contribute to individual risk stratification and well-founded treatment decisions in clinical routine. Especially the role of tricuspid regurgitation as a complication after TLE should be investigated in future studies.
Juni
Georgi C, Bannehr M, Lochmann M, Reiners D, Haase-Fielitz A, Butter C, Seifert M
Left atrial low-voltage areas, but not volume, predict the recurrence of atrial fibrillation in repeat ablation procedures
J Cardiovasc Electrophysiol. 2024 Jun;35(6):1156-1164
doi: 10.1111/jce.16266
Linksatriale Niederspannungsgebiete (low volatge areas, LVA) sind ein umstrittenes Ziel bei der Ablation von Vorhofflimmern. In der vorliegenden Studie wurden LA-Maps von 160 Patienten (50,6 % männlich, 60 % persistierendes Vorhofflimmern) analysiert. Patienten mit einem Rezidiv hatten einen signifikant höheren Prozentsatz an LVAs (40,0 % vs. 18,8 %, p < .001). Der prozentuale Anteil des gesamten LVA hat eine gute Vorhersagekraft für das Wiederauftreten von Arrhythmien in bei Patienten mit Wiederholungseingriffen, unabhängig von der angewandten Ablationsstrategie.
Introduction: Infections associated with cardiac implantable electronic devices (CIEDs) are a multifactorial disease that leads to increased morbidity and mortality.
Objective: The aim was to analyze patient-, disease- and treatment-related characteristics including microbiological and bacterial spectrum according to survival status and to identify risk factors for 1- and 3-year mortality in patients with local and systemic CIED infection.
Methods: In a retrospective cohort study, we analyzed data from patients with CIED-related local or systemic infection undergoing successful transvenous lead extraction (TLE). Survival status as well as incidence and cause of rehospitalization were recorded. Microbiology and antibiotics used as first-line therapy were compared according to mortality. Independent risk factors for 1- and 3-year mortality were determined.
Results: Data from 243 Patients were analyzed. In-hospital mortality was 2.5%. Mortality rates at 30 days, 1- and 3 years were 4.1%, 18.1% and 30%, respectively. Seventy-four (30.5%) patients had systemic bacterial infection. Independent risk factors for 1-year mortality included age (OR 1.05 [1.01-1.10], p = 0.014), NT-proBNP at admission (OR 4.18 [1.81-9.65], p = 0.001), new onset or worsened tricuspid regurgitation after TLE (OR 6.04 [1.58-23.02], p = 0.009), and systemic infection (OR 2.76 [1.08-7.03], p = 0.034), whereas systemic infection was no longer an independent risk factor for 3-year mortality. Staphylococcus aureus was found in 18.1% of patients who survived and in 25% of those who died, p = 0.092. There was a high proportion of methicillin-resistant strains among coagulase-negative staphylococci (16.5%) compared to Staphylococcus aureus (1.2%).
Conclusions: Staphylococci are the most common causative germs of CIED-infection with coagulase-negative staphylococci showing higher resistance rates to antibiotics. The independent risk factors for increased long-term mortality could contribute to individual risk stratification and well-founded treatment decisions in clinical routine. Especially the role of tricuspid regurgitation as a complication after TLE should be investigated in future studies.
April
Erfurt S, Lauxmann M, Asmus K, Oess S, Patschan D, Hoffmeister M
Serum Nostrin-A risk factor of death, kidney replacement therapy and acute kidney disease in acute kidney injury
PLoS One. 2024 Apr 11;19(4):e0299131
doi: 10.1371/journal.pone.0299131
In einem translationalen Forschungsansatz zwischen Biochemie und Nephrologie wurde das F-BAR Protein Nostrin als neuer prädiktiver Biomarker bei akuter Nierenschädigung (AKI) in Bezug auf AKI-assoziierte Mortalität, Notwendigkeit einer Nierenersatztherapie und Wiederherstellung der Nierenfunktion identifiziert. Im Vergleich zu Kontrollpersonen weisen AKI-Patient*innen signifikant höhere Nostrin-Level im Serum auf und die Nostrin-Level nehmen mit dem Schweregrad einer AKI signifikant zu. Niedrige Serum Nostrin-Level zum Zeitpunkt einer AKI-Diagnose sind prädiktiv für Überleben im Krankenhaus. Die Identifikation des neuen Biomarkers könnte zukünftig zu einer frühzeitigen Diagnose einer akuten Nierenschädigung und damit zu einem frühzeitigem und gezieltem Therapiebeginn beitragen.
Background: The prediction of Acute Kidney Injury (AKI)-related outcomes remains challenging. Persistent kidney excretory dysfunction for longer than 7 days has been defined as Acute Kidney Disease (AKD). In this study, we prospectively quantified serum Nostrin, an essential regulator of endothelial NO metabolism, in hospitalized patients with AKI.
Design, setting, participants, & measurements: In-hospital subjects with AKI of various etiology were identified through the in-hospital AKI alert system of the Brandenburg University Hospital. Serum Nostrin, and serum NGAL and KIM-1 were measured within a maximum of 48 hours from the timepoint of initial diagnosis of AKI. The following endpoints were defined: in-hospital death, need of kidney replacement therapy (KRT), recovery of kidney function (ROKF) until discharge.
Results: AKI patients had significantly higher serum Nostrin levels compared to Controls. The level of serum Nostrin increased significantly with the severity of AKI. Within the group of AKI patients (n = 150) the in-hospital mortality was 16.7%, KRT was performed in 39.3%, no ROKF occurred in 28%. Patients who required KRT had significantly higher levels of serum Nostrin compared to patients who did not require KRT. Significantly higher levels of serum Nostrin were also detected in AKI patients without ROKF compared to patients with ROKF. In addition, low serum Nostrin levels at the timepoint of AKI diagnosis were predictive of in-hospital survival. For comparison, the serum concentrations of NGAL and KIM-1 were determined in parallel to the Nostrin concentrations and the results confirm the prognostic properties of serum Nostrin in AKI.
Conclusions: The current study suggests serum Nostrin as novel biomarker of AKI-associated mortality, KRT and Acute Kidney Disease.
März
Hillmeister P, Li K, Dai M, Sacirovic M, Pagonas N, Ritter O, Bramlage P, Bondke Persson A, Buschmann I, Zemmrich C
Lipoprotein(a) as a risk factor for atherosclerotic cardiovascular disease in patients in non-metropolitan areas of Brandenburg, Germany
Front Cardiovasc Med. 2024 Mar 7;11:1302152.
doi: 10.3389/fcvm.2024.1302152
Die Non-Metropolregion Brandenburg ist durch hohe Raten an Herz-Kreislauf-Erkrankungen und unzureichende medizinische Versorgung geprägt. Diese UKB Lauflabor Studie zeigt erstmals für die Kohorte Brandenburg (n>500), dass erhöhte Lipoprotein(a)-Werte (Lp(a)) ein signifikanter und unabhängiger Risikofaktor für arteriosklerotische Herz-Kreislauf-Erkrankungen (ASCVD) ist. Es bestätigte sich hierbei, dass hohe Lp(a)-Werte unabhängig von Lebensstil-Faktoren wie körperlicher Aktivität oder Rauchverhalten sind und sich über einen Zeitraum von 12 Monaten nicht verändern. Diese Studie trägt dazu bei, das Bewusstsein für Lp(a) als stabiler Risikofaktor in unterversorgten Regionen zu erhöhen und kann helfen, diagnostische und therapeutische Strategien zur Verbesserung der Gesundheit von ASCVD Patientinnen und Patienten zu entwickeln.
Background and aims: In the non-metropolitan region of Brandenburg (Germany), which is characterized by high rates of cardiovascular diseases and underserved medical care, there is a lack of awareness regarding lipoprotein(a) [Lp(a)] as a risk factor. In addition, data from patients with atherosclerotic cardiovascular disease (ASCVD) in diverse regional backgrounds, including the understudied Brandenburg cohort, and various healthcare statuses remain insufficient.
Methods: In this WalkByLab study, Lp(a) levels were monitored in a non-metropolitan cohort (n = 850) in Brandenburg, Germany, comprising 533 patients at high cardiovascular risk and 317 healthy controls. Patients underwent a comprehensive angiological screening, which included blood serum analysis, assessment of medical and family history, cardiovascular risk, and disease status, and evaluation of lifestyle and quality of life. All parameters were evaluated with regard to two groups based on Lp(a) levels: low (<50 mg/dl) and high (≥50 mg/dl).
Results: Brandenburg patients with cardiovascular diseases showed higher Lp(a) levels than healthy controls (24.2% vs. 14.8%, p = 0.001). Logistic regression analysis with different characteristics revealed that Lp(a) was an independent risk factor significantly associated with ASCVD (OR 2.26, 95% CI 1.32-3.95, p = 0.003). The high-Lp(a) group showed a higher proportion of patients with coronary artery disease, peripheral artery disease, or cerebrovascular disease compared to the low-Lp(a) group (50% vs. 36.8%; 57.7% vs. 45.8%; 17.6% vs. 9.2%; p = 0.004); also, a higher percentage of patients in the high-Lp(a) group had heart failure (72.8% vs. 53.2%, p = 0.014) and myocardial infarction (24.7% vs. 13.9%, p = 0.001). The high-Lp(a) group exhibited higher rates of statins (63.1% vs. 50.4%, p = 0.003), ezetimibe (14.8% vs. 5.5.%, p = 0.001), and beta-blockers (55.7% vs. 40.7%, p = 0.001) use. Lp(a) levels were found to be independent of physical activity or smoking behavior and did not change over time (12 months).
Conclusions: Our study highlights the significance of elevated Lp(a) levels in Brandenburg cardiovascular patients and identifies them as an independent risk factor for ASCVD, which has implications for addressing cardiovascular health of non-metropolitan populations.
Februar
Mühlensiepen F, Hoffman MJ, Nübel J, Ignatyec Y, Heinze M, Butter C, Haase-Fielitz A
Acceptance of telemedicine by specialists and general practitioners in cardiology care: a cross-sectional survey study
JMIR Formative Research. 2024 accepted for publication / in press
https://doi.org/10.2196/preprints.49526
In den kommenden Jahren wird die Telemedizin eine Schlüsselrolle in der Gesundheitsversorgung spielen. Vor allem in ländlichen Gebieten mit schwacher Infrastruktur könnte die Telemedizin für eine angemessene und personalisierte medizinische Versorgung entscheidend sein. Im Rahmen einer webbasierten Umfrage untersuchten wir anhand eines Fragebogens die Akzeptanz und die Präferenzen der Telemedizin bei Kardiologen, Internisten und Allgemeinmedizinern. Von 929 kontaktierten Ärzten*innen füllten 12,1 % die Fragebögen aus. Etwa 16 % der Befragten nutzen Telemedizin derzeit täglich, 43 % überhaupt nicht. Insgesamt bewerteten 35,1 % ihre Kenntnisse über Telemedizin als sehr gut oder gut. Als Hindernisse für die Umsetzung wurden vor allem die Verwaltung (26,8 %), die unzureichende Kostenerstattung (25,8 %) und die Anschaffung der technischen Ausrüstung (23,7 %) genannt. Die Einstellung zur Telemedizin in der klinischen Praxis stand in engem Zusammenhang mit der Zahl der pro Jahresquartal behandelten Patienten. Unsere Ergebnisse deuten auf eine insgesamt mäßige Nutzung, aber positive Einstellung zur Telemedizin bei den Teilnehmern mit einer höheren klinischen Fallzahl hin. Das Fehlen eines strukturellen Rahmens scheint ein Hindernis für die effektive Einführung der Telekardiologie zu sein.
Background: In the coming years, telemedicine (TM) will play a key role in healthcare. Especially in rural areas with weak infrastructure, TM could be crucial to provide adequate and personalized medical care.
Objective: Therefore, we investigated the acceptance and preferences for the use of TM. Methods: Between May 2021 and February 2022, an online survey was conducted with cardiologists, internists and general practitioners focusing on cardiac care, working predominantly in outpatient and inpatient settings. Participants were contacted via their professional email addresses, via QR code published in a regional health journal, and via twitter. To classify survey participants based on their attitudes to telecardiology, multidimensional scaling (MDS) and a subsequent K-means clustering with the Kruskal-Wallis-test were used.
Results: Overall, 929 physicians were contacted. A total of 112 (12.1%) completed questionnaires were recorded. Participants were 56% male (54/97), 29% female (28/97), and 2% (2/97) diverse. The median age was 50 years. More than half of the participants (54.6%) did not use TM. Reported barriers to implementation were mostly administration (26.8%, 26/97), inadequate reimbursement (25.8%, 25/97) and the purchase of technology equipment (23.7%, 23/97). After exclusion of questionnaires with missed values, participants could be divided into three clusters (C1, C2, C3) based on different attitudes towards TM. Attitudes toward TM in clinical activities were closely related to the number of patients being treated per annual quarter: C3 (Median= 1350), vs. C1 (Median=750) and C2 (Median=500). The differences between clinical caseloads of C1-C3 members were significant: C1 vs C2 (P=.0271), C1 vs C3 (P=.0174), C2 vs C3 (P=.0001). Most participants (77.1 %) would like to expand TM approaches in the future. In the field of cardiology, the participants reported a high suitability of TM. Willingness to train in TM is high to very high in > 50% of the participants.
Conclusions: Our results indicate generally moderate use, but positive attitudes towards TM among participating physicians with a higher clinical caseload. The lack of a structural framework seems to be a barrier to the effective implementation of telecardiology.
Januar
Rebecca Lehmann, Oliver Ritter, Johanna Tennigkeit, Susann Patschan, Daniel Patschan
Multiple blood gas variables predict AKI survival in an independent manner
BMC Nephrol. 2024 Jan 23;25(1):28.
doi: 10.1186/s12882-024-03470-9
Die akute Nierenschädigung betrifft bis zu 30% aller stationär behandelten Patient:innen. Bislang gestaltet sich die Risikoprädiktion, also die Vorhersage von klinisch relevanten Endpunkten wie Tod oder Dialysetherapie bei den Betroffenen äußerst schwierig. In unserer Studie konnten wir zeigen, dass verschiedene Parameter aus venösen und arteriellen Blutgasanalysen (BGA) über prädikative Aussagekraft bei AKI-Pat. verfügen. Dabei lag zum BGA-Zeitpunkt in vielen Fällen eine AKI noch gar nicht vor. Blutgasanalysen sind kostengünstig zu erheben und vergleichsweise leicht interpretierbar. Sie bieten sich somit als additives Werkzeug in der AKI-Risikoprädiktion an.
Background and aim: Acute kidney injury (AKI) is becoming increasingly prevalent among hospitalized patients and carries a poor prognosis. While new biomarkers show promise in identifying early stages of AKI, accurately predicting severe outcomes such as the need for kidney replacement therapy (KRT) or death remains a challenge. However, blood gas analyses (BGA) can be used to diagnose life-threatening complications associated with AKI. The objective of this study was to assess the role of BGA as a biomarker panel in both emerging and established cases of AKI.
Methods: Retrospective observational study examining subjects with newly developed acute kidney injury (AKI). The study will document venous and arterial pH, pCO2, and actual bicarbonate levels upon hospital admission and at the onset of AKI. The primary endpoints include in-hospital mortality, the need for kidney replacement therapy (KRT), and the recovery of kidney function (ROKF).
Results: A total of 202 individuals were included in the study. Three variables were found to be independent predictors of in-hospital survival: admission arterial pH, arterial pH at acute kidney injury (AKI) onset, and arterial pCO2 at AKI onset. Additionally, venous pCO2 at AKI onset was identified as an independent predictor for the need of kidney replacement therapy (KRT).
Conclusions: Our study suggests that blood gas analysis may have a potential role in predicting severe outcome variables in acute kidney injury (AKI). The associated costs are minimal.
Dezember
Sawa Kostin, Manfred Richter, Natalia Ganceva, Benjamin Sasko, Theodoros Giannakopoulos, Oliver Ritter, Zoltan Szalay, Nikolaos Pagonas
Atrial fibrillation in human patients is associated with increased collagen type V and TGFbeta1
IJC Heart & Vasculature. 2023 Available online 27 December 2023. In Press, Corrected Proof
https://doi.org/10.1016/j.ijcha.2023.101327
Background and aim: Atrial fibrosis is an important factor in initiating and maintaining atrial fibrillation (AF). Collagen V belongs to fibrillar collagens. There are, however no data on collagen V in AF. The aim of this work was to study the quantity of collagen V and its relationship with the number of fibroblasts and TGF- b 1 expression in patients in sinus rhythm (SR) and in patients with atrial fibrillation (AF). Methods: We used quantitative immuhistochemistry to study collagen V in right and left atrial biopsies obtained from 35 patients in SR, 35 patients with paroxysmal AF (pAF) and 27 patients with chronic, long-standing persistent AF (cAF). In addition, we have quantified the number of vimentin-positive fibroblasts and expression levels of TGF-β1.
Results: Compared to patients in SR, collagen V was increased 1.8- and 3.1-fold in patients with pAF and cAF, respectively. In comparison with SR patients, the number of vimentin-positive cells increased significantly 1.46-and 1.8-fold in pAF and cAF patients, respectively. Compared to SR patients, expression levels of TGF-ß1, expressed as fluorescence units per tissue area, was significantly increased by 77 % and 300 % in patients with pAF and cAF, respectively. Similar to intensity measurements, the number of TGFß1-positive cells per 1 mm2 atrial tissue increased significantly from 35.5 ± 5.5 cells in SR patients to 61.9 ± 12.4 cells in pAF and 131.5 ± 23.5 cells in cAF. In both types of measurements, there was a statistically significant difference between pAF and cAF groups.
Conclusions: This is the first study to show that AF is associated with increased expression levels of collagen V and TGF-ß1indicating its role in the pathogenesis of atrial fibrosis. In addition, increases in collagen V correlate with increased number of fibroblasts and TGF-β1 and are more pronounced in cAF patients than those in pAF patients.
November
Filip Schröter, Ralf-Uwe Kühnel, Martin Hartrumpf, Roya Ostovar, Johannes Maximilian Albes
Progress on a Novel, 3D-Printable Heart Valve Prosthesis
Polymers (Basel). 2023 Nov 15;15(22):4413.
doi: 10.3390/polym15224413
Polymerische Herzklappen sind Prothesen aus flexiblen Kunststoffen, die eine langlebige und zugleich verträgliche Alternative zu den momentan genutzten Typen darstellen könnten. Sie werden derzeit in verschiedenen Arbeitsgruppen weltweit entwickelt, so auch am MHB-Standort Bernau. Das vorliegende Paper stellt den aktuellen Entwicklungsstand der sogenannten TIPI-Prothese vor, welche mit Hilfe moderner 3D-Drucktechniken bedeutend verbessert werden konnte. Perspektivisch wird diese Art der Forschung den Weg für preisgünstige, individuell maßgeschneiderte Prothesen zum Ersatz geschädigter Herzklappen ebnen.
(1) Background: Polymeric heart valves are prostheses constructed out of flexible, synthetic materials to combine the advantageous hemodynamics of biological valves with the longevity of mechanical valves. This idea from the early days of heart valve prosthetics has experienced a renaissance in recent years due to advances in polymer science. Here, we present progress on a novel, 3D-printable aortic valve prosthesis, the TIPI valve, removing the foldable metal leaflet restrictor structure in its center. Our aim is to create a competitive alternative to current valve prostheses made from flexible polymers. (2) Methods: Three-dimensional (3D) prototypes were designed and subsequently printed in silicone. Hemodynamic performance was measured with an HKP 2.0 hemodynamic testing device using an aortic valve bioprosthesis (BP), a mechanical prosthesis (MP), and the previously published prototype (TIPI 2.2) as benchmarks. (3) Results: The latest prototype (TIPI 3.4) showed improved performance in terms of regurgitation fraction (TIPI 3.4: 15.2 ± 3.7%, TIPI 2.2: 36.6 ± 5.0%, BP: 8.8 ± 0.3%, MP: 13.2 ± 0.7%), systolic pressure gradient (TIPI 3.4: 11.0 ± 2.7 mmHg, TIPI 2.2: 12.8 ± 2.2 mmHg, BP: 8.2 ± 0.9 mmHg, MP: 10.5 ± 0.6 mmHg), and effective orifice area (EOA, TIPI 3.4: 1.39 cm2, TIPI 2.2: 1.28 cm2, BP: 1.58 cm2, MP: 1.38 cm2), which was equivalent to currently used aortic valve prostheses. (4) Conclusions: Removal of the central restrictor structure alleviated previous concerns about its potential thrombogenicity and significantly increased the area of unobstructed opening. The prototypes showed unidirectional leaflet movement and very promising performance characteristics within our testing setup. The resulting simplicity of the shape compared to other approaches for polymeric heart valves could be suitable not only for 3D printing, but also for fast and easy mass production using molds and modern, highly biocompatible polymers.
Oktober
Ragna Iwers, Veronika Sliziuk, Michael Haase, Sophie Barabasch, Michael Zänker, Christian Butter and Anja Haase-Fielitz
Care Bundle for Acute Kidney Injury in Cardiac Patients: A Cluster-Randomized Trial
J Clin Med. 2023 Oct; 12(19): 6391.
doi: 10.3390/jcm12196391
Akute Nierenschädigung ist eine häufige und prognostisch relevante Erkrankung. Elektronische Frühwarnsysteme haben das Potential, eine akute Nierenschädigung frühzeitig zu detektieren und prozess- und patientenbezogene Endpunkte zu verbessern. In der vorliegenden Studie wurde die Wirksamkeit eines elektronischen Frühwarnsystems und eines Maßnahmenbündels im Rahmen einer randomisierten Studie bei 200 Patienten untersucht. Das Absetzen von blutdrucksenkenden Medikamenten während Phasen mit niedrigem, die Nieren möglicherweise schädigenden Blutdruck, fand bei Patienten in der Interventionsgruppe häufiger als bei Patienten in der Kontrollgruppe statt. Die Diagnose „Akute Nierenschädigung“ wurde bei Patienten der Interventionsgruppe häufiger im Entlass-Arztbrief für den weiterbehandelnden Haus- oder Facharzt dokumentiert.
ENGLISH ABSTRACT
September
Jonathan Nübel, Michael Hauptmann, Julika Schön, Georg Fritz, Christian Butter, Anja Haase-Fielitz
App-based assessment of memory functions in patients after transfemoral aortic valve replacement
J Geriatr Cardiol 2023 Sep 28;20(9):664-672.
doi: 10.26599/1671-5411.2023.09.004
Der Transfemorale Aortenklappen-Ersatz (TAVI) ist für ältere Patient*innen mit schwerer Aortenklappenstenose die Standardbehandlung. Trotz der Sicherheit und Etabliertheit der Methode besteht das Risiko von hämodynamischer Instabilität und stillen zerebralen Embolien während des Eingriffs. In der ersten Pilotstudie des POST-TAVI Projektes mit 141 Patient*innen zeigte sich, dass TAVI keine generelle Verschlechterung der Gedächtnisfunktion bewirkt. Interessanterweise wiesen viele Patient*innen bereits vor TAVI eine eingeschränkte Gedächtnisleistung auf.
ENGLISH ABSTRACT
Juli
Lubomir T Lubomirov, René Mantke, Thomas Enzmann, Doris Metzler, Tatiana Korotkova, Jürgen Hescheler, Gabriele Pfitzer, Olaf Grisk
ROK and RSK2-kinase pathways differ between senescent human renal and mesenteric arteries
J Hypertens 2023 Jul 1;41(7):1201-1214.
doi: 10.1097/HJH.0000000000003450
Die Arbeit zeigt für ältere Patient*innen, dass die Verengung von Blutgefäßen (kleine Arterien) der Niere stärker vom Enzym Rho-Kinase abhängt als bei kleinen Arterien, die den Darm versorgen. Das Enzym RSK2, welches die Gefäßverengung fördert, zeigt bei kleinen Nierenarterien älterer Patient*innen Zeichen einer stärkeren Aktivierung als bei entsprechenden Blutgefäßen des Darms. Bei gealterten Mäusen ist die RSK2-Aktivierung kleiner Nierenarterien, nicht jedoch bei kleinen Darmarterien, stärker als bei jungen Mäusen. Die Arbeit verbessert das Verständnis der Funktion von Blutgefäßen bei Alterung und liefert Befunde, die für die Entwicklung blutdrucksenkender Medikamente, deren Wirkung in der Erweiterung spezifischer Gefäßgebiete besteht, nützlich sind.
ENGLISH ABSTRACT
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Juni
Kangbo Li, Mengjun Dai, Mesud Sacirovic, Claudia Zemmrich, Nikolaos Pagonas, Oliver Ritter, Olaf Grisk, Lubomir T Lubomirov, Martin A Lauxmann, Peter Bramlage, Anja Bondke Persson, Eva Buschmann, Ivo Buschmann, Philipp Hillmeister
Leukocyte telomere length and mitochondrial DNA copy number associate with endothelial function in aging-related cardiovascular disease
Front Cardiovasc Med 2023 Jun 5:10:1157571.
doi: 10.3389/fcvm.2023.1157571.
Die Studie untersuchte die Zusammenhänge zwischen der Länge der Leukozyten-Telomere, der mitochondrialen DNA-Kopienzahl und der endothelialen Funktion bei Patienten mit altersbedingten Herz-Kreislauf-Erkrankungen (CVD). Die Ergebnisse zeigten eine positive Korrelation zwischen der Telomerlänge in zellfreier DNA (cf-TL) und der mitochondrialen DNA-Kopienzahl in zellfreier DNA (cf-mtDNA), sowie zwischen der Telomerlänge in Leukozyten-DNA (leu-TL) und der mitochondrialen DNA-Kopienzahl in Leukozyten-DNA (leu-mtDNA). Beide, leu-TL und leu-mtDNA, korrelierten positiv mit der endothelialen Funktion (FMD) und könnten daher als neue Biomarker für endotheliale Dysfunktion betrachtet werden.
ENGLISH ABSTRACT
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Mai
Mengjun Dai, Kangbo Li, Mesud Sacirovic, Claudia Zemmrich, Eva Buschmann, Oliver Ritter, Peter Bramlage, Anja Bondke Persson, Ivo Buschmann, Philipp Hillmeister
Autophagy-related genes analysis reveals potential biomarkers for prediction of the impaired walking capacity of peripheral arterial disease
BMC Med 2023 May 18;21(1):186.
doi: 10.1186/s12916-023-02889-5
Die Studie untersuchte die Rolle von Autophagie und autophagiebezogenen Genen bei peripherer arterieller Verschlusskrankheit (PAD) und identifizierte 20 relevante Gene mit niedriger Expression im atherosklerotischen Arterien bei PAD-Patienten. Die Expression von Autophagie-Markerproteinen war bei PAD-Patienten reduziert, und die Analyse zeigte eine starke Korrelation zwischen Autophagie-Genen und Immunfunktion, insbesondere Zytokin-Zytokin-Rezeptor-Interaktionen. Hier wurden besonders die Chemokine GRO und NAP2 als stark exprimierte Faktoren im Plasma von PAD-Patienten identifiziert, welches signifikant mit eingeschränkter Gehfähigkeit korrelierte. Das entwickelte Nomogramm-Modell zeigte für GRO und NAP2 ein starkes Potenzial zur Vorhersage von Gehkapazitäten bei PAD-Patienten (AUC: 0,860).
ENGLISH ABSTRACT
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April
Benny Rousso, Naama Winetraub, Boaz Rippin, Marvin Albrecht, Christian Butter
Prolonged Low-Intensity Ultrasound Delivery as Potential Kidneys Treatment for Acutely Decompensated Heart Failure Patients
JACC Basic Transl Sci 2023 Apr 24;8(4):389-391.
doi: 10.1016/j.jacbts.2023.03.008
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März
Nibras Soubh, Philipp Hillmeister, Eva Buschmann, Christian Klaproth, Ivo Buschmann
Tolerability safety and effectiveness of enhanced external counterpulsation versus individual shear rate therapy in patients with lower extremity atherosclerotic disease: A prospective pilot clinical trial
Acta Physiol (Oxf) 2023 Mar;237(3):e13913.
doi: 10.1111/apha.13913
In dieser Studie wurde die Verträglichkeit, Sicherheit und Wirksamkeit der extrakorporalen Pulsation mit einem Medizinprodukt untersucht, wobei die klassische enhanced external counterpulsation (EECP) Therapie mit der in der Hochschulklinik für Angiologie (UKB, MHB) neu entwickelten Individual shear rate therapy (ISRT) bei Patienten mit arteriosklerotischer Erkrankung der unteren Extremitäten (LEAD) verglichen wurde. Die Ergebnisse zeigten, dass EECP bei 55,6% der Patienten vorzeitig abgebrochen werden musste, hauptsächlich aufgrund von Unwohlsein, während 22,2% der Patienten unter EECP Anzeichen einer kritischen Extremitätenischemie zeigten. ISRT wurde im Vergleich gut vertragen und zeigte, dass die Sauerstoffsättigung, der Blutfluss und der relative Hämoglobingehalt in der Mikrozirkulation gesteigert werden konnte.
ENGLISH ABSTRACT.
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Februar
Kangbo Li, Victoria Kratzmann, Mengjun Dai, Nora Gatzke, Petra Rocic, Peter Bramlage, Olaf Grisk, Lubomir T Lubomirov, Meike Hoffmeister, Martin A Lauxmann, Oliver Ritter, Eva Buschmann, Michael Bader, Anja Bondke Persson, Ivo Buschmann, Philipp Hillmeister
Angiotensin receptor-neprilysin inhibitor improves coronary collateral perfusion
Front Cardiovasc Med 2023 Feb 3:9:981333.
In dieser Studie wurde der pleiotrope Effekt eines Angiotensin-Rezeptor-Neprilysin-Inhibitors (ARNi) auf die kollateralabhängige Myokardperfusion in einem Rattenmodell der koronaren Arteriogenese untersucht. Die in vivo Ergebnisse zeigten, dass ARNis die koronare kollaterale Perfusion signifikant verbesserten, sowie die Genexpression des Kallikrein-Kinin-Systems regulierten und die Effekte über Bradykinin Rezeptoren vermitteln.
ENGLISH ABSTRACT
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Januar
Roya Ostovar, Farzaneh Seifi Zinab, Filip Schröter, Martin Hartrumpf, Dirk Fritzsche, Johannes Maximilian Albes
Does Age Influence the Preoperative Condition and, Thus, the Outcome in Endocarditis Patients?
J Clin Med 2023 Jan 19;12(3):822.
doi: 10.3390/jcm12030822
Am Schwerpunkt beteiligte Arbeitsgruppen
Neues aus der Forschung
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DGK fördert Forschung zu altersbedingten Herzrhythmusstörungen
Die Deutsche Gesellschaft für Kardiologie (DGK) unterstützt die Forschung von Dr. Johanna Tennigkeit (AG Sachse/Ritter; IAG MMKE) mit einem Stipendium in Höhe von 50.000 Euro für die Dauer von 12 Monaten.
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MHB-Student Simon Seitz erhält das Otto-Hess-Promotionsstipendium der Deutschen Gesellschaft für Kardiologie
Die Deutsche Gesellschaft für Kardiologie vergibt ein Promotionsstipendium für die ultraschallbasierte Forschung im Bereich der Herzinsuffizienz.
Kontakt
Dr. rer. nat.
Gregor Sachse
Forschungskoordinator Bereich Herz/Kreislauf MHB Campus Brandenburg an der Havel
Telefonnummer: +49 3381 41-2666
E-Mail:
gregor.sachse@mhb-fontane.de
