Hans-Uwe Simon

Prof. Dr. med. Dr. h.c. mult. Simon
Titel: Prof. Dr. med. Dr. h.c. mult.
Aktuelle Position: Präsident
Fachbereich: kein
Medizinische Hochschule Brandenburg
Campus Neuruppin
Fehrbelliner Str. 38
16816 Neuruppin
Diensttelefon: +49 3391 39-14110
Dienst-E-Mail: hans-uwe.simon@mhb-fontane.de
In der MHB seit: 01.09.2021
Curriculum Vitae


Friedrich Schiller University Jena (Germany):
1980-1986 Medical School (magna cum laude)
1984 M.Sc.; Dipl.-med. (summa cum laude)
1985 M.D.; Dr. med. (summa cum laude)
1990 Specialization in Immunology (Facharzt)

University of Toronto (Canada), Mount Sinai Hospital and Toronto
General Hospital, Departments of Molecular Biology and Immunology:
1990-1992 Postdoctoral fellowship

University of Zurich (Switzerland):
1996 Venia legendi; PD Dr. med.

University of Jerusalem (Israel), Hadassah Medical School, Department of Pharmacology:
1996-2001 Ph.D.

University of Bern (Switzerland):
2000-2005 Specialization in Clinical Immunology (FAMH)

Medical Licensure:

MD No. 71/86, Gera 1986

Professional Positions in Medical Research and Teaching:


University of Zurich, Swiss Institute of Allergy and Asthma Research, Principle Investigator, Head of Asthma Research


Swiss Institute of Allergy and Asthma Research, Deputy Director, Principal Investigator


University of Bern, Director of the Department of Pharmacology, Principal Investigator, Full-Professor


University of Bern, Vice-Dean for Research, Faculty of Medicine


University of Bern, Dean, Faculty of Medicine


Medical University of Moscow – Department of Clinical Immunology and Allergology, Sechenov University, Moscow  (Russia), Full-Professor


Kazan Federal University – Institute of Fundamental Medicine and Biology, Kazan (Russia), Principal Investigator, Visiting Professor


University of Bern, Deputy Director of the Department of Pharmacology, Principal Investigator, Full-Professor


Brandenburg Medical School, Neuruppin, Germany, President

Additional Administrative and Advisory Posts:

  • Treasurer, European Cell Death Society (ECDO), 2000-2005
  • Member of the Executive Committee of the European Academy of Allergology and Clinical Immunology (EAACI), 2001-2003
  • Member of the Central Committee of the Union of the Swiss Societies for Experimental Biology (USGEB/USSBE), 2002-2007
  • Member of the Scientific Advisory Board, Society in Science: The Branco Weiss Fellowship, ETH Zürich, 2002-2008
  • President, Swiss Society of Pharmacology and Toxicology (SSPT), 2004-2007
  • Member of the Board, Section of Immunology of the European Academy of Allergology and Clinical Immunology (EAACI), 2003-2007
  • Member of the Ethics Committee, European Academy of Allergology and Clinical Immunology (EAACI), 2003-2007
  • Member of the Scientific Commission, Research Foundation of the University of Bern, 2005-2016
  • President, Swiss Society of Experimental Pharmacology (SSEP), 2005-2008
  • President, European Cell Death Society (ECDO), 2007-2009
  • President, Union of the Swiss Societies for Experimental Biology (USGEB / USSBE), 2007-2010
  • Member of the Scientific Commission, Swiss Cancer League, 2008-2017
  • Member of the Advisory Board, Helmholtz-Zentrum für Umweltforschung GmbH Leipzig (Germany), 2008-2012
  • Chairman of the Advisory Board, Helmholtz-Zentrum für Umweltforschung GmbH Leipzig (Germany), 2012-2014
  • Representative of the Mechanisms of Allergy/Asthma/Immunology (MAAI) section of the American Academy of Allergy, Asthma and Immunology (AAAAI), 2011-2015
  • Chair, committee “Cells and Cytokines” of the American Academy of Allergy, Asthma and Immunology (AAAAI), 2014-2016
    Member of the Council of the Collegium Internationale Allergologicum (CIA), 2010-2014
  • ERASMUS-Coordinator Pharmacology/Pharmacy, University of Bern, since 2011
  • Co-chair, Committee “Eosinophil, Mast Cell and Basophil Disorders in Allergic Disease”, World Allergy Organization (WAO), 2011-2015
  • Chairman of the Board of Trustees, Department of Clinical Research, Medical Faculty, University of Bern, 2012-2016
  • President, International Eosinophil Society (IES), 2013-2015
  • Vice-Chair, Immunopharmacology Section, International Union of Basic and Clinical Pharmacology (IUPHAR), since 2013
  • Chair, Task Force: Experimental Animal Center, University of Bern, 2013-2016
  • Member of the Scientific Executive Board of SystemsX.ch: The Swiss Initiative in Systems Biology, 2013-2016
  • Member of the Scientific Advisory Board of the Novartis Foundation, 2013-2017
  • Member of the Board of Directors, University Hospital Bern (Inselspital), 2016-2020
  • President, Collegium of the Deans of the Swiss Faculties of Medicine, 2018-2020
  • President, Scientific Advisory Board of the Novartis Foundation, since 2017
  • Panel Member, European Research Council (ERC), since 2019

Editorial Work in Scientific Journals:

1. APOPTOSIS Section Editor since 1996
2. INT. ARCH. ALLERGY IMMUNOL. Editorial Board 1998-2017
3. ALLERGY Advisory Board 1999-2002
4. ALLERGY Associate Editor 2003-2010
5. ALLERGOLOGIE Editorial Board since 1999
6. INT. J. HYG. ENVIRON. HEALTH Editorial Board since 2000
7. EXP. CLIN. ALLERGY Editorial Board 2001-2009
8. ALLERGO-JOURNAL Editorial Board since 2001
9. PLANTA MEDICA Advisory Board 2004-2006
10. J. ALLERGY CLIN. IMMUNOL. Editorial Board 2005-2010
11. CELL DEATH DIFFER. Section Editor since 2006
12. MOL. CELL. PHARMACOL. Editorial Board since 2008
13. ALLERGY Editor-in-Chief 2010-2018
14. CELL DEATH DISEASE Section Editor 2010-2016
15. FRONTIERS IN ONCOLOGY Associate Editor 2010-2019
16. CELL DEATH DISEASE Editor-in-Chief since 2016
17. J. IMMUNOLOGY Associate Editor since 2017
18. INT. ARCH. ALLERGY IMMUNOL. Editor-in-Chief since 2018
19. CELL DEATH DIFFER/DIS/DISCOV Ethics Committee since 2020
20. SEM. IMMUNOPATHOLOGY Guest Editor 2021

Selected Awards:

  • Paul Martini Prize, Paul Martini Foundation, Wiesbaden (D), April 1997
  • Georg Friedrich Götz Prize, University of Zurich, Medical Faculty, Zurich (CH), December 2000
  • Pfizer Research Prize, Zurich (CH), February 2003
  • Member of the German National Academy of Sciences Leopoldina, 2009
  • Member of the Swiss Academy of Medical Sciences, 2013
  • Doctor honoris causa, University of Ljubljana, December 2017
  • Phoenix Science Prize, November 2020
  • Doctor honoris causa, South Ural State Medical University, June 2021
Selected original publications: (h-index: 90; citations: 38’990; Scopus ID number: 7402135360; ORCID ID number: orcid.org/0000-0002-9404-7736)
1. H.-U. Simon, G.B. Mills, S. Hashimoto, K.A. Siminovitch:
Evidence for defective transmembrane signaling in B cells from patients with WiskottAldrich syndrome.
J. Clin. Invest. 90 (1992), 1396-1405.
2. S. Yousefi, D.R. Green, K. Blaser, H.-U. Simon:
Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils.
Proc. Natl. Acad. Sci. USA 91 (1994), 10868-10872.
3. H.-U. Simon, S. Yousefi, C. C. Dommann-Scherrer, D. R. Zimmermann, S. Bauer, J. Barandun, K. Blaser:
Expansion of cytokine producing CD4-CD8- T cells associated with abnormal Fas expression and hypereosinophilia.
J. Exp. Med. 183 (1996), 1071-1082.
Comment in: J. Exp. Med. 183 (1996), 721-724 (Lenardo MJ)
4. S. Yousefi, D. C. Hoessli, K. Blaser, G. B. Mills, H.-U. Simon:
Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in freshly isolated eosinophils.
J. Exp. Med. 183 (1996), 1407-1414.

5. M. Roth, M. Nauck, S. Yousefi, M. Tamm, K. Blaser, A.P. Perruchoud, H.-U. Simon:
Platelet-activating factor exerts mitogenic activity and stimulates expression of interleukin-6 and interleukin-8 in human lung fibroblasts via binding to its functional receptor.
J. Exp. Med. 184 (1996), 191-201.
6. H. Hebestreit, B. Dibbert, I. Balatti, D. Braun, A. Schapowal, K. Blaser, H.-U. Simon:
Disruption of Fas receptor signaling by nitric oxide in eosinophils.
J. Exp. Med. 187 (1998), 415-425.
7. H.-U. Simon, S. Yousefi, B. Dibbert, H. Hebestreit, D.R. Branch, K. Blaser, F. Levi-Schaffer, G.P. Anderson:
Role of tyrosine  phosphorylation and Lyn tyrosine kinase in Fas receptor-mediated apoptosis in eosinophils.
Blood 92 (1998), 547-557.
8. B. Dibbert, I. Daigle, D. Braun, C. Schranz, M. Weber, K. Blaser, U. Zangemeister-Wittke, A.N. Akbar, H.-U. Simon:
Role for Bcl-xL in delayed eosinophil apoptosis mediated by granulocyte-macrophage colony-stimulating factor and interleukin-5.
Blood 92 (1998), 778-783.
9. B. Dibbert, M. Weber, W.H. Nikolaizik, M.H. Schöni, P. Vogt, K. Blaser, H.-U. Simon:
Cytokine-mediated Bax deficiency associated with delayed neutrophil apoptosis in inflammation.
Proc. Natl. Acad. Sci. USA 96 (1999), 13330-13335.
10. H.-U. Simon, S.G. Plötz, R. Dummer, K. Blaser:
Abnormal clones of T cells producing interleukin 5 in idiopathic eosinophilia.
N. Engl. J. Med. 341 (1999), 1112-1120.
Comment in: N. Engl. J. Med. 341 (1999), 1141-1143 (Bain BJ)
Comment in: N. Engl. J. Med. 342 (1999), 659-660 (Guitart J)
Comment in: N. Engl. J. Med. 342 (1999), 660 (Roufosse F et al.)
Comment in: N. Engl. J. Med. 342 (1999), 660 (Suzuki R et al.)
11. I. Daigle, S. Yousefi, M. Colonna, D.R. Green, H.-U. Simon:
Death receptors bind SHP-1 and block cytokine-induced antiapoptotic signaling in neutrophils.
Nat. Med. 8 (2002), 61-67.
12. A. Straumann, H.P. Spichtin, L. Grize, K.A. Bucher, C. Beglinger, H.-U. Simon:
Natural history of primary eosinophilic esophagitis: A follow-up of 30 adult patients for up to 11.5 years.
Gastroenterology 125 (2003), 1660-1669.
Comment in: Gastroenterology 127 (2004), 364 (Langdon DE)

13. S.G. Plötz*, H.-U. Simon*, U. Darsow, D. Simon, E. Vassina, S. Yousefi, R. Hein, T. Smith, H. Behrendt, J. Ring:
Use of an anti-interleukin-5 antibody in the hypereosinophilic syndrome with eosinophilic dermatitis.
N. Engl. J. Med. 349 (2003), 2334-2339.
*Shared First-Authorship
14. F. Altznauer, S. Martinelli, S. Yousefi, C. Thürig, I. Schmid, E.M. Conway, M.H. Schöni, P. Vogt, C. Mueller, M.F. Fey, U. Zangemeister-Wittke, H.-U. Simon:
Inflammation-associated cell-cycle-independent block of apoptosis by survivin interminally differentiated neutrophils.
J. Exp. Med. 199 (2004), 1343-1354.
15. S. von Gunten, S. Yousefi, M. Seitz, S.M. Jakob, T. Schaffner, R. Seger, J. Takala, P.M. Villiger, H.-U. Simon:
Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the pro-inflammatory cytokine environment.
Blood 106 (2005), 1423-1431.
16. S. von Gunten, A. Schaub, M. Vogel, B.M. Stadler, S. Miescher, H.-U. Simon:
Immunologic and functional evidence for anti-Siglec-9 autoantibodies in intravenous immunoglobulin (IVIg) preparations.
Blood 108 (2006), 4255-4259.
Comment in: J. Perinatology 27 (2007), 196-197 (Buenz EJ & Howe CL)
17. S. Yousefi, R. Perozzo, I. Schmid, A. Ziemiecki, T. Schaffner, L. Scapozza, T. Brunner, H.-U. Simon:
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat. Cell Biol. 8 (2006), 1124-1132.
Comment in: Nature Cell Biology 8 (2006), 1045-1047 (Codogno P & Meijer AJ)
Comment in: Nature Reviews Molecular Cell Biology 7 (2006), 796-797 (Heinrichs A)
18. S. Conus, R. Perozzo, T. Reinheckel, C. Peters, L. Scapozza, S. Yousefi, H.-U. Simon:
Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation.
J. Exp. Med. 205 (2008), 685-698.
Comment in: Nature Reviews Immunology 8 (2008), 244 (Tufet M)
Comment in: J. Exp. Med. 205 (2008), 505 (Bashyam H)

19. S. Yousefi, J.A. Gold, N. Andina, J.J. Lee, A.M. Kelly, E. Kozlowski, I. Schmid, A. Straumann, J. Reichenbach, G.J. Gleich, H.-U. Simon: Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense.
Nat. Med. 14 (2008), 949-953.
Comment in: Nature Medicine 14 (2008), 910-912 (Nizet V & Rothenberg ME)
Comment in: Nature Reviews Immunology 8 (2008), 658 (Leavy O)
Comment in: Science 321 (2008), 1021 (PAK)
Comment in: J. Allergy Clin. Immunol. 122 (2008), 661 (Gabbert S)
20. A. Straumann, S. Conus, P. Grzonka, H. Kita, G. Kephart, C. Bussmann, C. Beglinger, D.A. Smith, J. Patel, M. Byrne, H.-U. Simon: Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomized, placebo-controlled, double-blind trial.
Gut 59 (2010), 21-30.
21. A. Straumann, S. Conus, L. Degen, S. Felder, M. Kummer, H. Engel, C. Bussmann, C. Beglinger, A. Schoepfer, H.-U. Simon: Budesonide is effective in adolescent and adult patients with active eosinophilic esophagitis.
Gastroenterology 139 (2010), 1526-1537.
Comment in: Gastroenterology 139 (2010), 1429-1430 (Tack J and Carethers JM)
22. B. Geering, U. Gurzeler, E. Federzoni, T. Kaufmann, H.-U. Simon:
A novel TNFR1-triggered apoptosis pathway mediated by class IA PI3Ks in neutrophils.
Blood 117 (2011), 5953-5962.
23. S. Salemi, S. Yousefi, M.A. Constantinescu, M.F. Fey, H.-U. Simon:
Autophagy is required for self-renewal and differentiation of adult human stem cells.
Cell Res. 22 (2012), 432-435.
24. D. Maskey, S. Yousefi, I. Schmid, I. Zlobec, A. Perren, R. Friis, H.-U. Simon:
A novel role for ATG5 in drug-induced mitotic catastrophe independent of autophagy.
Nat. Commun. 4 (2013), 2130.
25. H. Liu, Z. He, T. von Rütte, S. Yousefi, R.E. Hunger, H.-U. Simon:
Downregulation of autophagy-related protein 5 (ATG5) contributes to the pathogenesis of early-stage cutaneous melanoma. Sci. Transl. Med. 5 (2013), 202ra123.
26. A. Soragni, S. Yousefi, C. Stoeckle, A.B. Soriaga, M.R. Sawaya, E. Kozlowski, I., Schmid, S. Radonjic-Hoesli, S. Boutet, G.J. Williams, M. Messerschmidt, M.M. Seibert, D. Cascio, N.A. Zatsepin, M. Burghammer, C. Riekel, J.-P. Colletier, R. Riek, D. Eisenberg, H.-U. Simon: Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation.
Mol. Cell 57 (2015), 1011-1021.

27. S. Radonjic-Hoesli, X. Wang, E. de Graauw, C. Stoeckle, B. Styp-Rekowska, R. Hlushchuk, D. Simon, P.J. Spaeth, S. Yousefi, H.-U. Simon: Adhesion-induced eosinophil cytolysis requires the RIPK3-MLKL signaling pathway which is counter-regulated by autophagy. J. Allergy
Clin. Immunol. 140 (2017), 1632-1642.
Comment in: J. Allergy Clin. Immunol. 140 (2017), 1548-1549 (Renz H)
28. P. Amini, D. Stojkov, A. Felser, C.B. Jackson, C. Courage, A. Schaller, L. Gelman, M.E. Soriano, J.M. Nuoffer, L. Scorrano, C. Benarafa, S. Yousefi, H.-U. Simon: Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production.
Nat. Commun. 9 (2018), 2958.
29. H. Liu, Z. He, N. Germic, H. Ademi, Z. Frangez, A. Felser, J.-M. Nuoffer, C. Bovet, I. Mlinaric-Rascan, I. Zlobec, M. Fiedler, A. Perren, H.-U. Simon: ATG12 deficiency leads to tumor cell oncosis owing to diminished mitochondrial biogenesis and reduced cellular bioenergetics.
Cell Death Differ. 27 (2020), 1965-1980.
30. N. Germic, A. Hosseini, D. Stojkov, K. Oberson, M. Claus, C. Benarafa, S. Calzavarini, A. Angelillo-Scherrer, I.C. Arnold, A. Müller, C. Riether, S. Yousefi, H.-U. Simon: ATG5 promotes eosinopoiesis, but inhibits eosinophil effector functions.
Blood 137 (2021), 2958-2969.
31. T. Greuter, A. Straumann, Y. Fernandez-Marrero, N. Germic, A. Hosseini, S. Yousefi, D. Simon, M.H. Collins, C. Bussmann, M. Chehade, E.S. Dellon, G.T. Furuta, N. Gonsalves, I. Hirano, F.J. Moawad, L. Biedermann, E. Safroneeva, A.M. Schoepfer, H.-U. Simon: Characterization of eosinophilic esophagitis variants by clinical, histological and molecular analyses: a cross-sectional multicenter study.
Allergy 2021, in revision.