Katarzyna Jóźwiak

Dr. Jóźwiak
Current position:Scientific personnel
Specialist field:Biometrie und Registerforschung
Office address:

Institut für Biometrie und Registerforschung
Fehrbelliner Str. 38
16816 Neuruppin

Office phone number:+49 3391 39 14584
Curriculum Vitae

Dr. Katarzyna Jóźwiak obtained a Master's degree in Applied Mathematics from Delft University, The Netherlands, in 2008, and in Econometrics and Computer Science from the University of Zielona Góra, Poland, in 2009. As a graduate student in Applied Statistics at Utrecht University, The Netherlands, she investigated optimal designs of trials with discrete-time survival endpoints and completed her PhD in 2013. After a brief period as software developer at Utrecht University, Dr. Jóźwiak worked at the Netherlands Cancer Institute in Amsterdam (The Netherlands), till June 2019 where she collaborated as a senior statistician with clinicians and other researchers of the Institute and the Antoni van Leeuwenhoek hospital. Since 2019, Dr. Jóźwiak is a senior statistician at the Institute of Biostatistics and Registry Research. For a complete CV, click here.


Groot HJ, Van Leeuwen FE, Lubberts S, Horenblas S, De Wit R, Alfred Witjes J, Groenewegen G, Poortmans PM, Hulshof MCCM, Meijer OWM, De Jong IJ, Van den Berg HA, Smilde TJ, Vanneste BGL, Aarts MJ, Jóźwiak K, Van den Belt-Dusebout AW, Gietema JA, Schaapveld M. "Platinum exposure and cause-specific mortality among testicular cancer patients." Cancer. In press

Van der Willik KD, Hauptmann M, Jóźwiak K, Vinke EJ, Ruiter R, Stricker BH, Compter A, Ikram MA, Schagen SB. "Trajectories of cognitive performance prior to cancer diagnosis: a population-based study." J Natl Cancer Inst. In press

Kho E, De Boer LL, Post AL, Van de Vijver KK, Jóźwiak K, Sterenborg HJCM, Ruers TJM. "Imaging depth variations in hyperspectral imaging: development of a method to detect tumor up to the required tumor-free margin width." J Biophotonics. In press

Min LA, Vogel WV, Lahaye MJ, Maas M, Donswijk M, Vegt E, Kusters M, Zijlmans HJ, Jóźwiak K, Roberti S, Beets-Tan RGH, Lambregts DMJ. "Integrated versus separate reading of [18F]FDG-PET/CT and MRI for abdominal malignancies effect on staging outcomes and diagnostic confidence." Eur Radiol, 2019; 29: pp. 6900-6910.

Puppe J, Opdam M, Schouten PC, Jóźwiak K, Lips E, Severson T, Van de Ven M, Brambil- lasca C, Bouwman P, Van Tellingen O, Bernards R, Wesseling J, Eichler C, Thangarajah F, Malter W, Pandey GK, Ozretic L, Caldas C, Van Lohuizen M, Hauptmann M, Rhiem K, Hahnen E, Reinhardt HC, Buttner R, Mallmann P, Schomig-Markiefka B, Schmutzler R, Linn S, Jonkers J. "EZH2 is overexpressed in BRCA1-like breast tumors and predictive for sensitivity to high-dose platinum-based chemotherapy." Clin Cancer Res, 2019; 25: pp. 4351-52.

Elbers JBW, Veldhuis LI, Bhairosing PA, Smeele LE, Jóźwiak K, Van den Brekel MWM, Verheij M, AlMamgani A, Zuur CL. "Salvage surgery for advanced stage head and neck squamous cell carcinoma following radiotherapy or chemoradiation." Eur Arch Otorhinolaryngol, 2019; 276: pp. 647-655.

Berger DMS, Wassenberg RM, Jóźwiak K, Van de Wiel BA, Balm AJM, Van den Berg JG, Klop WMC. "Inter-observer variation in the histopathology reports of head and neck melanoma; a comparison between the seventh and eighth edition of the AJCC staging system." Eur J Surg Oncol, 2019; 45(2): pp. 235-241.

Elbers JBW, Al-Mamgani A, Van den Brekel MWM, Jóźwiak K, De Boer JP, Lohuis PJFM, Willems SM, Verheij M, Zuur CL. "Salvage surgery for recurrence after radiotherapy for squamous cell carcinoma of the head and neck". Otolaryngol Head Neck Surg, 2019; 160(6): pp. 1023-1033.

Van Eden WJ, Kok NFM, Snaebjornsson P, Jóźwiak K, Woensdregt K, Bottenberg P, Boot H, Aalbers AGJ. "Factors inuencing long-term survival after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei originating from appendiceal neoplasms." BJS Open, 2019; 3: pp. 376-386.

Madu MF, Franke V, Van de Wiel BA, Klop WMC, Jóźwiak K, Van Houdt WJ, Wouters MWJM, Van Akkooi ACJ. "External validation of the 8th edition melanoma staging system of the American Joint Committee on Cancer (AJCC): Effect of adding EORTC sentinel node (SN) tumor burden criteria on prognostic accuracy in stage III." J Clin Oncol, 2018; 36(15 suppl): 9500-9500.

Kuusk T, De Bruijn R, Brouwer OR, De Jong J, Donswijk M, Hendricksena K, Horenblas S, Jóźwiak K, Prevoo W, Valds Olmos RA, Van Der Poel HG, Van Rhijn BWG, Wit EM, Bex A. "Outcome of sentinel lymph node biopsy in patients with clinically non-metastatic renal cell carcinoma." Scan J of Urology, 2018; 52(5-6): pp. 411-418.

Krul IMK, Opstal-Van Winden AWJ, Janus CPM, Daniels LA, Appelman Y, Maas AHEM, De Vries S, Jóźwiak K, Aleman BMP, Van Leeuwen F. "Cardiovascular disease risk after treatment-induced premature ovarian insufficiency in female survivors of Hodgkin lymphoma." J Am Coll Cardiol, 2018; 72(25): pp. 3374-3375.

Kuusk T, Donswijk ML, Valdes Olmos RA, De Bruijn RE, Brouwer OR, Hendricksen K, Horenblas S, Jóźwiak K, Prevoo W, Van Der Poel HG, Van Rhijn BWG, Wit EM, Bex A. "An analysis of SPECT/CT non-visualization of sentinel lymph nodes in renal tumors." Eur J Nucl Med Mol Imaging, 2018; 8: 105.

Groot HJ, Gietema JA, Aleman BMP, Incrocci L, De Wit R, Witjes AJ, Groenewegen G, De Brouwer P, Meijer OWM, Hulshof MCCM, Van den Berg HA, Smilde TJ, Vanneste BGL, Aarts MJ, Van den Bergh ACM, Kerst JM, Van den Belt-Dusebout AW, Lubberts S, Jóźwiak K, Horenblas S, Van Leeuwen FE, Schaapveld M. "Risk of diabetes after para-aortic radiation for testicular cancer". Br J Cancer, 2018; 119: pp. 901-907.

Ottenhof SR, Djajadiningrat RS, Thygesen HH, Jakobs PJ, Jóźwiak K, Heeren AM, De Jong J, Sanders J, Horenblas S, Jordanova ES. "The prognostic value of immune factors in the tumor microenvironment of penile squamous cell carcinoma." Frontiers in Immunology, 2018; 9: 1253.

Groot HJ, Lubberts S, De Wit R, Witjes JA, Kerst JM, De Jong IJ, Groenewegen G, Van den Eertwegh AJM, Poortmans PM, Klumpen H, Van den Berg HA, Smilde TJ, Vanneste BGL, Aarts MJB, Incrocci L, Van den Bergh ACM, Jóźwiak K, Van den Belt-Dusebout AW, Horenblas S, Gietema JA, Van Leeuwen FE, Schaapveld M. "Risk of solid cancer after treatment for testicular germ cell cancer in the platinum era." J Clin Oncol, 2018; 36(4): pp. 2504-2513.

Brouwer de Koning SG, Vranken Peeters MTFD, Jóźwiak K, Bhairosing P, Ruers TJM. "Tumor resection margin definitions in breast-conserving surgery: Systematic review and meta- analysis of the current literature". Clin Breast Cancer, 2018; 18(4): e595-e600.

Volders JH, Negenborn VL, Haloua MH, Krekel NMA, Jóźwiak K, Meijer S,Van den Tol MP. "Breast-specific factors determine cosmetic outcome and patient satisfaction after breast-conserving therapy: Results from the randomized COBALT study." J Surg Oncol, 2018; 117: pp. 1001-1008.

De Vries S, Schaapveld M, Van Nimwegen FA, Jóźwiak K, Lugtenburg PJ, Daniels LA, Roesink JM, Van der Maazen RWM, Kok WEM, Aleman BMP, Van Leeuwen FE. "High burden of subsequent malignant neoplasms and cardiovascular disease in long-term Hodgkin lymphoma survivors." Br J Cancer, 2018; 118: pp. 887-895.

Dackus GM, Jóźwiak K, Sonke GS, Van der Wall E, Van Diest PJ, Hauptmann M, Siesling S, Linn SC. "Optimal adjuvant endocrine treatment of ER+/HER2+ breast cancer patients by age at diagnosis: A population-based cohort study". Eur J Cancer, 2018; 90: pp. 92-101.

Elbers JBW, Al-Mamgani A, Paping D, Van den Brekel MWM, Jóźwiak K, De Boer JP, Karakullukcu B, Verheij M, Zuur CL. "Definitive (chemo)radiotherapy is a curative alternative for standard of care in advanced stage squamous cell carcinoma of the oral cavity." Oral Oncol, 2017; 75: pp. 163-168.

Dackus GMHE, Ter Hoeve ND, Opdam M, Vreuls W, Varga Z, Koop EA, Willems SM, Van Deurzen CHM, Groen EJ, Cordoba A, Bart J, Mooyaart AL, Van den Tweel JG, Zolota V, Wesseling J, Sapino A, Chmielik E, Ryska A, Amant F, Broeks A, Kerkhoven R, Stathonikos N, Veta M, Voogd A, Jóźwiak K, Hauptmann M, Hoogstraat M, Schmidt MK, Sonke GS, Van der Wall E, Siesling S, Van Diest PJ, Linn SC. "Long-term prognosis of young breast cancer patients (≤40 years) who did not receive adjuvant systemic treatment: protocol for the PARADIGM initiative cohort study." BMJ Open, 2017; 7(11): e017842.

Madu MF, Franke V, Bruin MM, Berger DMS, Bierman C, Jóźwiak K, Klop WMC, Wouters MWJM, Akkooi ACJ, Van de Wiel BA. "Immediate completion lymph node dissection in stage IIIA melanoma does not provide significant additional staging information beyond EORTC SN tumor burden criteria." Eur J Cancer, 2017; 87: pp. 212-215.

Kadouch DJ, Elshot YS, Zupan-Kajcovski B, Van Haersma de With ASE, Van der Wal AC, Leeang M, Jóźwiak K, Wolkerstorfer A, Bekkenk MW, Spuls PI, De Rie MA. "One-stop-shop with confocal microscopy imaging versus standard of care surgical treatment of basal cell carcinoma: an open label, non-inferiority, randomized controlled multicenter trial." Br J Dermatol, 2017; 177: pp. 735-741.

Madu MF, Schopman JHH, Berger DMS, Klop WMC, Jóźwiak K, Wouters MWJM, Van der Hage JA, Van Akkooi ACJ. "Clinical prognostic markers in stage IIIC melanoma." J Surg Oncol, 2017; 116: pp. 244-251.

Volders JH, Negenborn VL, Haloua MH, Krekel NMA, Jóźwiak K, Meijer S, Van den Tol MP. "Cosmetic outcome and quality of life are inextricably linked in breast conserving therapy." J Surg Oncol, 2017; 115: pp. 941-948.

Rigter LS, Spaander MCW, Moons LM, Bisseling TM, Aleman BMP, De Boer JP, Lugtenburg PJ, Janus CPM, Petersen EJ, Roesink JM, Raemaekers JMM, Van der Maazen RWM, Cats A, Bleiker EMA, Snaebjornsson P, Carvalho B, Lansdorp-Vogelaar I, Jóźwiak K, Te Riele H, Meijer GA, Van Leeuwen FE, Van Leerdam ME. "Colorectal cancer surveillance in Hodgkin lymphoma survivors at increased risk of therapy-related colorectal cancer: study design." BMC Cancer, 2017; 17(1), pp. 112.

Madu MF, Deken MM, Van der Hage JA, Jóźwiak K, Wouters MWJM, Van Akkooi ACJ. "Isolated limb perfusion for melanoma is safe and effective in elderly patients." Ann Surg Oncol, 2017; 24: pp. 1997-2005.

Volders JH, Haloua MH, Krekel NMA, Negenborn VL, Kolk RHE, Lopes Cardozo AMF, Bosch AM, De Widt-Levert LM, Van der Veene H, Rijna H, Taets van Amerongen AHM, Jóźwiak K, Meijer S, va den Tol MP. "Intraoperative ultrasound guidance in breast-conserving surgery shows superiority in oncological outcome, long-term cosmetic and patient-reported outcomes: Final outcomes of a randomized controlled trial (COBALT)." EJSO, 2017; 43(4): pp. 649-657.

Van Eden WJ, Kok NFM, Jóźwiak K, Beets GL, Van Leerdam ME, Boot H, Aalbers AGJ. "Timing of systemic chemotherapy in patients with colorectal peritoneal carcinomatosis treated wit cytoreductive surgery and hyperthermic intraperitoneal chemotherapy." Dis Colon Rectum, 2017; 60(5): pp. 477-487.

De Boer LL, Hendriks BHW, Van Duijnhoven F, Vrancken Peeters-Baas M-JTFD, Van de Vijver K, Loo CE, Jóźwiak K, Sterenborg HJCM, Ruers TJM. "Using DRS during breast conserving surgery: identifying robust optical parameters and influence of inter-patient variation." Biomed Opt Express, 2016; 7 (12): pp. 5188-5200.

Ter Brugge P, Kristel P, Van der Burg E, Boon U, De Maaker M, Lips E, Mulder L, de Ruiter J, Moutinho C, Gevensleben H, Marangoni E, Majewski I, Jóźwiak K, Kloosterman W, Van Roosmalen M, Duran K, Hogervorst F, Turner N, Esteller M, Cuppen E, Wesseling J, Jonkers J. "Mechanisms of therapy resistance in patient-derived xenograft models of BRCA1-deficient breast cancer." J Natl Cancer Inst, 2016; 108 (11).

Madu MF, Wouters MWJM, Klop WMC, Van der Hiel B, Van de Wiel BA, Jóźwiak K, Van der Hage JA, Van Akkooi ACJ. "Clinical prognostic markers in stage III-B melanoma." Ann Surg Oncol, 2016; 23 (13): pp. 4195-4202.

Van den Belt-Dusebout AW, Spaan M, Lambalk CB, Kortman M, Laven JSE, Van Santbrink EJP, Van der Westerlaken LAJ, Cohlen BJ, Braat DDM, Smeenk JMJ, Land JA, Goddijn M, Van Golde RJT, Van Rumste MM, Schats R, Jóźwiak K, Hauptmann M, Rookus MA, Burger CW, Van Leeuwen FE. "Ovarian stimulation for in vitro fertilization and long-term risk of breast cancer." JAMA, 2016; 316 (3): pp. 300-312.

Volders JH, Haloua MH, Krekel NMA, Negenborn VL, Barbe E, Sietses C, Jóźwiak K, Meijer S, Van den Tol MP. "Neoadjuvant chemotherapy in breast-conserving surgery - Consequences on margin status and excision volumes: A nationwide pathology study." Eur J Surg Oncol, 2016; 42(7): pp. 986-993.

Haloua MH, Volders JH, Krekel NMA, Barbe E, Sietses C, Jóźwiak K, Meijer S, Van den Tol MP. "A nationwide pathology study on surgical margins and excision volumes after breast-conserving surgery: There is still much to be gained." The Breast, 2016; 25: pp. 14-21.

Haloua MH, Volders JH, Krekel NMA, Lopes Cardozo AMF, De Roos WK, De Widt-Levert LM, Van der Veen H, Rijna H, Bergers E, Jóźwiak K, Meijer S, Van den Tol MP. "Intra-operative ultrasound guidance in breast-conserving surgery improves cosmetic outcomes and patient satisfaction: Results of a multicenter randomized controlled trial (COBALT)." Ann Surg Oncol, 2016; 23 (1): pp. 30-37.

Theunissen EAR, Zuur CL, Jóźwiak K, Lopez-Yurda M, Hauptmann M, Rasch CRN, Van der Baan S, De Boer JP, Dreschler WA, Balm AJM. "Prediction of hearing loss due to cisplatin chemoradiotherapy." JAMA Otolaryngol Head Neck Surg, 2015; 141(9): pp. 810-815.

Jóźwiak K, Moerbeek M. "Optimal designs for trials with discrete-time survival endpoints." OA Epidemiology, 2013; 1(3): 22. Invited paper.

Moerbeek M, Jóźwiak K. "Optimal designs for event history analysis." Zeitschrift für Psychologie, 2013; 221(3): pp. 160-173. Invited paper for special issue on optimal designs.

Jóźwiak K, Moerbeek M. "PODSE: A computer Program for Optimal design of trials with Discrete-time Survival Endpoints." Comput Methods Programs Biomed, 2013; 111: pp. 115- 127.

Jóźwiak K, Moerbeek M. "Optimal treatment allocation and study duration for trials with discrete-time survival endpoints." J Stat Plan Inference, 2013; 143: pp. 971-982.

Jóźwiak K, Moerbeek M. "Accrual by groups in trials with discrete-time survival endpoints." Clinical Trials, 2012; 10: pp. 32-42.

Jóźwiak K, Moerbeek M. "Cost-effective designs for trials with discrete-time survival endpoints." Comput Stat Data Anal, 2012; 56: pp. 2086-2096.

Jóźwiak K, Moerbeek M. "Power analysis for trials with discrete-time survival endpoints." J Educ Behav Stat, 2012: 37(5): pp. 630-654.

Kurowicka D, Nauta M, Jóźwiak K, Cooke R. "Updating parameters of the chicken processing line model." Risk Analysis, 2010; 30(6): pp. 934-944.